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These include tumor protein p53, cyclin-dependent kinase inhibitor 2A, phosphatase and tensin homolog, retinoblastoma, hypoxia-inducible factors, and matrix metalloproteinases (MMPs), among others [7–11]

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Metabolic Function and Transport of Cobalamin in Human Cell Cobalamin Chemical Forms and Activation of Cbl-Dependent Enzymes The upper ligand of Cbl has a major role in activation of the Cbl-dependent enzymes